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xanthohumol  (MultiTarget Pharmaceuticals)

 
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    MultiTarget Pharmaceuticals xanthohumol
    Xanthohumol, supplied by MultiTarget Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/xanthohumol/product/MultiTarget Pharmaceuticals
    Average 90 stars, based on 1 article reviews
    xanthohumol - by Bioz Stars, 2026-02
    90/100 stars

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    XN and HOP EX affect HNSCC cell viability: ( A ) <t>Xanthohumol</t> chemical structure. ( B ) Viability assay measured by MTT (concentration range 0–25 µM XN, 0–1% HOP EX) at 48 h post-treatment. ( C ) Apoptosis analysis by Annexin V/PI assay 48 h post-treatment with IC50 (original plot Fig. C) ( D ) Synergyfinder + analysis shows significant synergism in combinations of XN + Cisplatin in UMSCC-103 and CAL-33. ( E ) Western blot results and quantification of BAX/BCL2 ratio in XN, Cisplatin, and combination treatment compared to the control. ( F ) Synergyfinder + analysis shows significant synergism in combinations of XN + Cisplatin in UMSCC-103 cis-R. ( G ) XN sensitivity (MTT assay) of UMSCC-103 cis-R cells.
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    XN and HOP EX affect HNSCC cell viability: ( A ) Xanthohumol chemical structure. ( B ) Viability assay measured by MTT (concentration range 0–25 µM XN, 0–1% HOP EX) at 48 h post-treatment. ( C ) Apoptosis analysis by Annexin V/PI assay 48 h post-treatment with IC50 (original plot Fig. C) ( D ) Synergyfinder + analysis shows significant synergism in combinations of XN + Cisplatin in UMSCC-103 and CAL-33. ( E ) Western blot results and quantification of BAX/BCL2 ratio in XN, Cisplatin, and combination treatment compared to the control. ( F ) Synergyfinder + analysis shows significant synergism in combinations of XN + Cisplatin in UMSCC-103 cis-R. ( G ) XN sensitivity (MTT assay) of UMSCC-103 cis-R cells.

    Journal: Scientific Reports

    Article Title: Xanthohumol modulate autophagy and ER stress to counteract stemness and enhance cisplatin efficacy in head and neck squamous cell carcinoma

    doi: 10.1038/s41598-025-98003-1

    Figure Lengend Snippet: XN and HOP EX affect HNSCC cell viability: ( A ) Xanthohumol chemical structure. ( B ) Viability assay measured by MTT (concentration range 0–25 µM XN, 0–1% HOP EX) at 48 h post-treatment. ( C ) Apoptosis analysis by Annexin V/PI assay 48 h post-treatment with IC50 (original plot Fig. C) ( D ) Synergyfinder + analysis shows significant synergism in combinations of XN + Cisplatin in UMSCC-103 and CAL-33. ( E ) Western blot results and quantification of BAX/BCL2 ratio in XN, Cisplatin, and combination treatment compared to the control. ( F ) Synergyfinder + analysis shows significant synergism in combinations of XN + Cisplatin in UMSCC-103 cis-R. ( G ) XN sensitivity (MTT assay) of UMSCC-103 cis-R cells.

    Article Snippet: Xanthohumol pure extract (XN) and Xanthohumol Hop extract 2% purity (HOP-EX) were obtained from Greensky.

    Techniques: Viability Assay, Concentration Assay, Western Blot, Control, MTT Assay